![]() Our findings demonstrate the limited value of Tcap to detect ventilation to perfusion ratio ( ) mismatch, following severe lung injury. Elevated PEEP increased PaO 2/FiO 2 and decreased Qs/Qt, which was reflected only in the Vcap slope ratio (Sn3 V/Sn2 V, p < 0.05). Conversely, Vcap indices exhibited consistent changes and provided excellent diagnostic value in detecting lung-function deterioration subsequent to lung injury. 77.3 ± 17.1 mmHg, p < 0.05) and compromised all mechanical parameters significantly, whereas Tcap parameters exhibited contradictory or inconsistent changes. ![]() Lung injury deteriorated the PaO 2/FiO 2 (baseline vs. All measurements were made under baseline conditions, and, following lung injury, under moderate (6 cmH 2O) and high PEEP levels (9 cmH 2O). Lung oxygenation index (PaO 2/FiO 2) and intrapulmonary shunt (Qs/Qt) were derived from arterial and central venous blood gas samples. ![]() Vcap was also used to estimate Enghoff’s physiological dead space (VD E). Mainstream Tcap and Vcap were performed to assess normalized phase 2 (Sn2 T, Sn2 V) and phase 3 slopes (Sn3 T, Sn3 V) in the time and volumetric domains. Lung injury was induced by iv lipopolysaccharide, whole lung lavage and injurious ventilation in anesthetized, mechanically ventilated rabbits ( n = 26). We compared the diagnostic value of indices derived from Tcap and Vcap following ventilation to perfusion ratio ( ) mismatch subsequent to experimentally induced acute respiratory distress syndrome (ARDS), and alveolar recruitment by elevating the positive end-expiratory pressure (PEEP). Whereas time capnography (Tcap) is routinely displayed during mechanical ventilation, the volumetric representation (Vcap) is seldom used. ![]()
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